Computational Personal Genomics: Making Sense of Complete Genomes

A pencil drawing of a double helix.

A sketch of the DNA double helix by Francis Crick, one of the discoverers of the structure of DNA. (Courtesy of The Wellcome Trust, License CC-BY.)


MIT Course Number


As Taught In

Spring 2016



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Course Description

Course Description

With the growing availability and lowering costs of genotyping and personal genome sequencing, the focus has shifted from the ability to obtain the sequence to the ability to make sense of the resulting information. This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences in gene expression, disease predisposition, or response to treatment.

Related Content

Manolis Kellis. 6.881 Computational Personal Genomics: Making Sense of Complete Genomes. Spring 2016. Massachusetts Institute of Technology: MIT OpenCourseWare, License: Creative Commons BY-NC-SA.

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