Protein Folding and Human Disease

Protein folding factors, illustrated as a series of lines and rectangles folded into different combinations of spirals and shapes.

(Image by MIT OpenCourseWare, adapted from image by Professor Jonathan King.)


MIT Course Number

7.88J / 5.48J / 10.543J

As Taught In

Spring 2015



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Course Description

Course Features

Course Description

This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper.

Other Versions

Related Content

Jonathan King. 7.88J Protein Folding and Human Disease. Spring 2015. Massachusetts Institute of Technology: MIT OpenCourseWare, License: Creative Commons BY-NC-SA.

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