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The effect of age on reproduction in men and women

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Allen, E. G., S. B. Freeman, et al. "Maternal Age and Risk for Trisomy 21 Assessed by the Origin of Chromosome Nondisjunction: A Report from the Atlanta and National Down Syndrome Projects." Human Genetics 125, no. 1 (2009): 41–52.

Robertshaw, I., J. Khoury, et al. "The Effect of Paternal Age on Outcome in Assisted Reproductive Technology Using the Ovum Donation Model." Reproductive Sciences 21, no. 5 (2014): 590–93.


Gonadal stem cells

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Johnson, J., J. Bagley, et al. "Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood." Cell 122, no. 2 (2005): 303–15.

Eggan, K., S. Jurga, et al. "Ovulated Oocytes in Adult Mice Derive from Non-circulating Germ Cells." Nature 441, no. 7097 (2006): 1109–114.


Cryopreservation of human embryos and oocytes

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Trounson, A., and L. Mohr. "Human Pregnancy following Cryopreservation, Thawing and Transfer of an Eight-cell Embryo." Nature 305, no. 5936 (1983): 707–9.

Wennerholm, U. B., V. Söderström-Anttila, et al. "Children Born After Cryopreservation of Embryos or Oocytes: A Systematic Review of Outcome Data." Human Reproduction 24, no. 9 (2009): 2158–72.


Characterization of infertility

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Rosen, Mitchell P., Barbara Sternfeld, et al. "Antral Follicle Count: Absence of Significant Midlife Decline." Fertility and Sterility 94, no. 6 (2010): 2182–185.

Oates, R. D., S. Silber, et al. "Clinical Characterization of 42 Oligospermic or Azoospermic Men with Microdeletion of the AZFc Region of the Y Chromosome, and of 18 Children Conceived via ICSI." Human Reproduction 17, no. 11 (2002): 2813–24.


Sex chromosome constitution and fertility

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Hunt, P. A., C. Worthman, et al. "Germ Cell Loss in the XXY Male Mouse: Altered X-chromosome Dosage Affects Prenatal Development." Molecular Reproduction and Development 49, no. 9 (1998): 101-11.

Lin, B., F. Tan, et al. "De Novo Structure Variations of the Y Chromosome in a 47,XXY Female with Ovarian Failure: A Case Report." Cytogenetic and Genome Research 143, no. 4 (2014): 221–4.


Embryo culture, assessment, selection and transfer

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Rienzi, L., A. Capalbo, et al. "No Evidence of Association Between Blastocyst Aneuploidy and Morphokinetic Assessment in a Selected Population of Poor-prognosis Patients: A Longitudinal Cohort Study." Reproductive Biomedicine Online 30, no. 1 (2015): 57–66.

Wells, D., K. Kaur, et al. "Clinical Utilisation of a Rapid Low-pass Whole Genome Sequencing Technique for the Diagnosis of Aneuploidy in Human Embryos Prior to Implantation." Journal of Medical Genetics 51, no. 8 (2014): 553–62.


Visit to Boston area IVF clinic

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Mouse models with abnormal reproductive phenotypes

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Ferguson, L., J. J. How, et al. "The Fate of Spermatogonial Stem Cells in the Cryptorchid Testes of RXFP2 Deficient Mice." PLoS One 8, no. 10 (2013): e77351.

Youngren, K. K., D. Coveney, et al. "The Ter Mutation in the Dead End Gene Causes Germ Cell Loss and Testicular Germ Cell Tumours." Nature 435, no. 7040 (2005): 360–64.


Seminal fluid–more than just a carrier of sperm

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Bromfield, J. J., J. E. Schjenken, et al. "Maternal Tract Factors Contribute to Paternal Seminal Fluid Impact on Metabolic Phenotype in Offspring." Proceedings of the National Academy of Sciences of the United States of America 111, no. 6 (2014): 2200–05.

Crawford, G., A. Ray, et al. "The Role of Seminal Plasma for Improved Outcomes During in Vitro Fertilization Treatment: Review of the Literature and Meta-analysis." Human Reproduction Update 21, no. 2 (2015): 275–84.


Promise and challenges in reprogramming adult cells to gametes

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Hayashi, K., S. Ogushi, et al. "Offspring from Oocytes Derived from in Vitro Primordial Germ Cell-like Cells in Mice." Science 338, no. 6109 (2012): 971–5.

Irie, N., L. Weinberger, et al. "SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate." Cell 160, no. 1–2 (2015): 253–68.


Student paper presentations and discussions

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