Required Reading

Martin, S. J. "Destabilizing influences in apoptosis: Sowing the seeds of IAP destruction." Cell 109 (2002): 793-796.

Palaga, T., and B. Osborne. "The 3D's of apoptosis: death, degredation and DIAPs." Nature Cell Biology 4 (2002): E149-E151.

Clemens, J. C., et al. "Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways." PNAS 97, no. 12 (2000): 6499-6503.

Kumar, S., and J. Doumanis. "The fly caspases." Cell Death and Differentiation 7 (2000): 1039-1044.

References for Background Material

Danial, N., and S. Korsmeyer. "Cell death: Critical Control Points." Cell 116 (2004): 205-219.

Hannon, G. J. "RNA interference." Nature 48 (2002): 244-251.

Worby, C. A., et al. "RNA interference of gene expression (RNAi) in cultured Drosophila cells." Science's STKE 2001 (August 14, 2001): 95.

Wilson, R. et al. "The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis." Nature Cell Biology 4 (2002): 445- 450.

References for Projects P2 and P3

Di Cristofano, A., and P. P. Pandolfi. "The multiple roles of PTEN in tumor suppression." Cell 100 (2000): 387-90.

Scheid, M. P., and J. R. Woodgett. "PKB/AKT: Functional insights from genetic models." Nature Reviews Molecular Cell Biology 2 (2001): 760-8.

Morrison, D. K., M. S. Murakami, and V. Cleghon. "Protein kinases and phosphatases in the Drosophila genome." Journal of Cell Biology 150 (2000): F57-62.

Li, X., A. Scuderi, A. Letsou, and D. M. Virshup. "B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster." Molecular Cell Biology 22 (2002): 3674-84.

Silverstein, A. M., C. A. Barrow, A. J. Davis, and M. C. Mumby. "Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits." PNAS 99 (2002): 4221-6.