Foundations of Algorithms and Computational Techniques in Systems Biology

Predicted 3-D structure of the Rad checkpoint complex.

The role of the Rad checkpoint complex was inferred from the 3-D structure predicted by comparative modeling at Lawrence Livermore National Laboratory. The Rad complex delays cell division to allow time for DNA repair to take place. (Image courtesy of the U.S. Department of Energy Genomics: GTL Program.)


MIT Course Number

20.482J / 6.581J

As Taught In

Spring 2006



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Course Description

Course Features

Course Description

This subject describes and illustrates computational approaches to solving problems in systems biology. A series of case-studies will be explored that demonstrate how an effective match between the statement of a biological problem and the selection of an appropriate algorithm or computational technique can lead to fundamental advances. The subject will cover several discrete and numerical algorithms used in simulation, feature extraction, and optimization for molecular, network, and systems models in biology.

Related Content

Bruce Tidor, and Jacob White. 20.482J Foundations of Algorithms and Computational Techniques in Systems Biology. Spring 2006. Massachusetts Institute of Technology: MIT OpenCourseWare, License: Creative Commons BY-NC-SA.

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