Functional Magnetic Resonance Imaging: Data Acquisition and Analysis

fMRI images and bar charts comparing responses to verum and sham acupuncture treatments.

A recently published study conducted by some HST.583 instructors used fMRI to assess the brain basis of pain relief underlying acupuncture and expectancy-evoked placebo treatments. (Source: Kong, J., T. J. Kaptchuk, G. Polich, I. Kirsch, M. Vangel, C. Zyloney, B. Rosen, and R. Gollub. "Expectancy and treatment interactions: A dissociation between acupuncture analgesia and expectancy evoked placebo analgesia." NeuroImage 45, no. 3 (15 April 2009): 940-949. doi:10.1016/j.neuroimage.2008.12.025. Courtesy of Elsevier, Inc., . Used with permission.)


MIT Course Number


As Taught In

Fall 2008



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Course Description

Course Features

Course Description

This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment.

Additional Faculty

Div Bolar

Dr. Bradford Dickerson

Dr. John Gabrieli

Dr. Doug Greve

Dr. Karl Helmer

Dr. Dara Manoach

Dr. Jason Mitchell

Dr. Christopher Moore

Dr. Vitaly Napadow

Dr. Jon Polimeni

Dr. Sonia Pujol

Dr. Bruce Rosen

Dr. Mert Sabuncu

Dr. David Salat

Dr. Robert Savoy

Dr. David Somers

Dr. A. Gregory Sorensen

Dr. Christina Triantafyllou

Dr. Wim Vanduffel

Dr. Mark Vangel

Dr. Lawrence Wald

Dr. Susan Whitfield-Gabrieli

Dr. Anastasia Yendiki

Other Versions

Related Content

Randy Gollub. HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis. Fall 2008. Massachusetts Institute of Technology: MIT OpenCourseWare, License: Creative Commons BY-NC-SA.

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